Pete E Pascuzzi

University Title:
Assistant Professor
Division/Unit(s):
Health & Life Sciences
Location(s):
Wilmeth Active Learning Center
3053A

Professional Information

Faculty Rank:
Assistant Professor
Liaison Areas:
Biochemistry
Bioinformatics
Biological Sciences
Medicinal Chemistry
Molecular Biosciences
Molecular Pharmacology
Courses Taught:
ILS 590 Independent Study in Information Sciences
ILS 595 Data Management at the Bench
BCHM 495 R for Molecular Biosciences
BCHM 498 Research in Biochemistry
BCHM 612 Bioinformatic Analysis of Genome Scale Data
Education:
Ph.D. Biochemistry, Cornell University, Ithaca, NY, 2006.
B.A. Biology and Chemistry, Washington & Jefferson College, Washington, PA, 1997.
Professional Experience:
Associate Member, Purdue University Center for Cancer Research, 2015 -
Assistant Professor of Biochemistry (by courtesy), Department of Biochemistry, Purdue University, 2014 -
Assistant Professor, Purdue University Libraries, Purdue University, 2013 -
Research Associate, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 2012 - 2013.
Postdoctoral Research Associate, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 2007 - 2012.
Honors and Awards:
Award for Excellence in Teaching, Libraries and School of Information Studies, 2019.
The John H. Moriarity Award for Excellence in Service to the Purdue University Libraries, 2018.
Seed for Success Award, Purdue University, Elizabeth Tran, Pete E. Pascuzzi and Weiguo A. Tao, 2017.

The Dean's Team Award, Get a G.R.I.P. Task Force, 2015.

Publications

Corresponding author

Co-corresponding author

  • Wang S, Xing Z, Pascuzzi PE, Tran EJ. Metabolic Adaptation to Nutrients Involves Co-regulation of Gene Expression by the RNA Helicase Dbp2 and the Cyc8 Co-repressor in Saccharomyces cerevisiae. G3 (Bethesda). 2017 May 12. pii: g3.117.041814. doi: 10.1534/g3.117.041814. PubMed PMID: 28500049. https://www.ncbi.nlm.nih.gov/pubmed/28500049.

  • Cloutier SC, Wang S, Ma WK, Al Husini N, Dhoondia Z, , Ansari A, Pascuzzi PE, Tran EJ. Regulated Formation of lncRNA-DNA Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation. Mol Cell. 2016 Feb 4;61(3):393-404. PubMed PMID: 26833086; NIHMSID: NIHMS748935; PubMed Central PMCID: PMC4744127. https://www.ncbi.nlm.nih.gov/pubmed/26833086.

Coauthor

  • Kim JI, Zhang X, Pascuzzi PE, Liu CJ, Chapple C. Glucosinolate and phenylpropanoid biosynthesis are linked by proteasome-dependent degradation of PAL. New Phytol. 2019 Aug 13. doi: 10.1111/nph.16108. PubMed PMID: 31408530. https://www.ncbi.nlm.nih.gov/pubmed/31408530

  • Farah E, Li C, Cheng L, Kong Y, Lanman NA, Pascuzzi PE, Lorenz GR, Zhang Y, Ahmad N, Li L, Ratliff T, Liu X. NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 Apr 2. pii: jbc.RA118.006983. doi: 10.1074/jbc.RA118.006983. PubMed PMID: 30940724. https://www.ncbi.nlm.nih.gov/pubmed/29700003

  • Zhang Z, Cheng L, Li J, Farah E, Atallah NM, Pascuzzi PE, Gupta S, Liu X. Inhibition of the Wnt/β-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer. Cancer research. 2018; 78(12):3147-3162 PMID: 29700003, PMCID: PMC6004251. https://www.ncbi.nlm.nih.gov/pubmed/?term=29700003
  • Carter B, Bishop B, Ho KK, Huang R, Jia W, Zhang H, Pascuzzi PE, Deal RB, Ogas J. The Chromatin Remodelers PKL and PIE1 Act in an Epigenetic Pathway That Determines H3K27me3 Homeostasis in Arabidopsis. The Plant Cell. 2018; 30(6):1337-1352. PMID: 29802212, PMCID: PMC6048792. https://www.ncbi.nlm.nih.gov/pubmed/?term=29802212

  • Concia L, Brooks AM, Wheeler E, Zynda GJ, Wear EE, LeBlanc C, Song J, Lee TJ, Pascuzzi PE, Martienssen RA, Vaughn MW, Thompson WF, Hanley-Bowdoin L. Genome-Wide Analysis of the Arabidopsis Replication Timing Program. Plant Physiology. 2018; 176(3):2166-2185. PMID: 29301956, PMCID: PMC5841712. https://www.ncbi.nlm.nih.gov/pubmed/?term=29802212

  • Goode KM, Petrov D, Vickman RE, Crist SA, Pascuzzi PE, Ratliff TL, Jo Davisson V, Hazbun TR. Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. Biochim Biophys Acta. 2017 May 8. pii: S0304-4165(17)30150-2. doi: 10.1016/j.bbagen.2017.05.006. PMID: 28495207. https://www.ncbi.nlm.nih.gov/pubmed/28495207

  • Thangamani S, Maland M, Mohammad H, Pascuzzi PE, Avramova L, Koehler CM, Hazbun TR, Seleem MN. Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway. Front Cell Infect Microbiol. 2017 Jan 18;7:4. doi: 10.3389/fcimb.2017.00004. PubMed PMID: 28149831; PubMed Central PMCID: PMC5241286.
    https://www.ncbi.nlm.nih.gov/pubmed/28149831

  • Mani SK, Zhang H, Diab A, Pascuzzi PE, Lefrançois L, , Fares N, Bancel B, Merle P, Andrisani O. EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. J Hepatol. 2016 Nov;65(5):888-898. PubMed PMID: 27238755. https://www.ncbi.nlm.nih.gov/pubmed/27238755

  • Thangamani S, Eldesouky HE, Mohammad H, Pascuzzi PE, Avramova L, , Hazbun TR, Seleem MN. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. Biochim Biophys Acta. 2016 Oct 3;1861(1 Pt A):3002-3010. PubMed PMID: 27712973. https://www.ncbi.nlm.nih.gov/pubmed/27712973

  • Ma J, Brennan KJ, D'Aloia MR, Pascuzzi PE, Weake VM. Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development. G3 (Bethesda). 2016 Aug 9;6(8):2435-45. PubMed PMID: 27261002; PubMed Central PMCID: PMC4978897. https://www.ncbi.nlm.nih.gov/pubmed/27261002

  • Fan H, Zhang H, Pascuzzi PE, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016 Feb 11;35(6):715-26. PubMed PMID: 25893293; NIHMSID: NIHMS671673; PubMed Central PMCID: PMC4615262. https://www.ncbi.nlm.nih.gov/pubmed/25893293

  • Wendt MK, Williams WK, Pascuzzi PE, Balanis NG, Schiemann BJ, , Carlin CR, Schiemann WP. The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6. Neoplasia. 2015 Jan;17(1):124-33. PubMed PMID: 25622905; PubMed Central PMCID: PMC4309683. https://www.ncbi.nlm.nih.gov/pubmed/25622905

NCBI Bibliography

https://www.ncbi.nlm.nih.gov/sites/myncbi/pete.pascuzzi.1/bibliography/45150274/public/?sort=date&direction=descending

Presentations

Oral Presentation

  • Zakharov, W., LI, H., Fosmire, M. J., Traynor, A., Pascuzzi, P. E. (Contributor), 2018 Pacific-Rim Objective Measurement Symposium (PROMS), "Supporting students’ self and peer assessment for writing assignments with Gradient," China. (2018).

Invited panel

Peer-reviwed posters

  • Sapp Nelson, M. (Author & Presenter), Pascuzzi, P. E. (Author), Research Data Access and Preservation Summit, "Developing an active learning graduate data course," ASSIST, Chicago, IL, United States. (March 2018).
  • Pascuzzi, P. E. (Author & Presenter), Embedding Data Literacy Instruction in an Introductory Bioinformatics Course, Poster: ACRL, Portland, OR, United States. (March 2015).