ppascuzz | Purdue Libraries

Pete E Pascuzzi

University Title:

Associate Professor

Division/Unit(s):

Science and Engineering Libraries

Location(s):

Wilmeth Active Learning Center

3053A

Professional Information

Faculty Rank:

Associate Professor

Liaison Areas:

Biochemistry

Bioinformatics

Biological Sciences

Medicinal Chemistry

Molecular Biosciences

Molecular Pharmacology

Courses Taught:

ILS 590 Independent Study in Information Sciences

BCHM 421 R for Molecular Biosciences

BCHM 498 Research in Biochemistry

BCHM 612 Bioinformatic Analysis of Genome Scale Data

Education:

Ph.D. Biochemistry, Cornell University, Ithaca, NY, 2006.

B.A. Biology and Chemistry, Washington & Jefferson College, Washington, PA, 1997.

Professional Experience:

Associate Member, Purdue University Center for Cancer Research, 2015 -

Associate Professor of Biochemistry (by courtesy), Department of Biochemistry, Purdue University, 2014 -

Associate Professor, Purdue University Libraries, Purdue University, 2013 - 2020

Research Associate, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 2012 - 2013.

Postdoctoral Research Associate, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 2007 - 2012.

Honors and Awards:

Award for Excellence in Teaching, Libraries and School of Information Studies, 2019.

The John H. Moriarity Award for Excellence in Service to the Purdue University Libraries, 2018.

Seed for Success Award, Purdue University, Elizabeth Tran, Pete E. Pascuzzi and Weiguo A. Tao, 2017.

The Dean's Team Award, Get a G.R.I.P. Task Force, 2015.

Publications

Corresponding author

Pascuzzi PE, Sapp Nelson MR. Integrating Data Science Tools into a Graduate Level Data Management Course. Journal of eScience Librarianship. 2018 December 20; 7(3). https://doi.org/10.7191/jeslib.2018.1152
Wang S, Gribskov M, Hazbun TR, Pascuzzi PE. CellMiner Companion: an interactive web application to explore CellMiner NCI-60 data. Bioinformatics. 2016 Aug 1;32(15):2399-401. PubMed PMID: 27153600.
- paper: https://www.ncbi.nlm.nih.gov/pubmed/?term=27153600
- github: https://github.com/pepascuzzi/CellMinerCompanion.git
- omics tools: https://omictools.com/cellminer-companion-tool

Co-corresponding author

Wang S, Xing Z, Pascuzzi PE, Tran EJ. Metabolic Adaptation to Nutrients Involves Co-regulation of Gene Expression by the RNA Helicase Dbp2 and the Cyc8 Co-repressor in Saccharomyces cerevisiae. G3 (Bethesda). 2017 May 12. pii: g3.117.041814. doi: 10.1534/g3.117.041814. PubMed PMID: 28500049. https://www.ncbi.nlm.nih.gov/pubmed/28500049.
Cloutier SC, Wang S, Ma WK, Al Husini N, Dhoondia Z, Ansari A, Pascuzzi PE, Tran EJ. Regulated Formation of lncRNA-DNA Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation. Mol Cell. 2016 Feb 4;61(3):393-404. PubMed PMID: 26833086; NIHMSID: NIHMS748935; PubMed Central PMCID: PMC4744127. https://www.ncbi.nlm.nih.gov/pubmed/26833086.

Coauthor

DeMarco A.G., Pascuzzi P.E., Tao W.A., Hall M.C. (2021) Phosphatase and Kinase Substrate Specificity Profiling with Pooled Synthetic Peptides and Mass Spectrometry. In: Coutts A.S., Weston L. (eds) Cell Cycle Oscillators. Methods in Molecular Biology, vol 2329. Humana, New York, NY. doi.org/10.1007/978-1-0716-1538-6_5
Zakharov, W., Li, H., Fosmire, M., Pascuzzi, P.E., Harbor, J. A mixed method study of self- and peer-assessment: Implications of grading online writing assignments on scientific news literacy. College & Undergraduate Libraries 2021, DOI: 10.1080/10691316.2021.1889426
Venkatraman P, Mills-Henry I, Padmanabhan KR, Pascuzzi P, Hassan M, Zhang J, Zhang X, Ma P, Pang CP, Dowling JE, Zhang M, Leung YF. Rods contribute to visual behavior in larval zebrafish. Invest Ophthalmol Vis Sci. 2020. PMID: 33049059, PMCID: PMC7571310 , DOI: 10.1167/iovs.61.12.11
Kim JI, Zhang X, Pascuzzi PE, Liu CJ, Chapple C. Glucosinolate and phenylpropanoid biosynthesis are linked by proteasome-dependent degradation of PAL. New Phytol. 2019 Aug 13. doi: 10.1111/nph.16108. PubMed PMID: 31408530. https://www.ncbi.nlm.nih.gov/pubmed/31408530
Farah E, Li C, Cheng L, Kong Y, Lanman NA, Pascuzzi PE, Lorenz GR, Zhang Y, Ahmad N, Li L, Ratliff T, Liu X. NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 Apr 2. pii: jbc.RA118.006983. doi: 10.1074/jbc.RA118.006983. PubMed PMID: 30940724. https://www.ncbi.nlm.nih.gov/pubmed/29700003
Zhang Z, Cheng L, Li J, Farah E, Atallah NM, Pascuzzi PE, Gupta S, Liu X. Inhibition of the Wnt/β-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer. Cancer research. 2018; 78(12):3147-3162. PMID: 29700003, PMCID: PMC6004251. https://www.ncbi.nlm.nih.gov/pubmed/?term=29700003
Carter B, Bishop B, Ho KK, Huang R, Jia W, Zhang H, Pascuzzi PE, Deal RB, Ogas J. The Chromatin Remodelers PKL and PIE1 Act in an Epigenetic Pathway That Determines H3K27me3 Homeostasis in Arabidopsis. The Plant Cell. 2018; 30(6):1337-1352. PMID: 29802212, PMCID: PMC6048792. https://www.ncbi.nlm.nih.gov/pubmed/?term=29802212
Concia L, Brooks AM, Wheeler E, Zynda GJ, Wear EE, LeBlanc C, Song J, Lee TJ, Pascuzzi PE, Martienssen RA, Vaughn MW, Thompson WF, Hanley-Bowdoin L. Genome-Wide Analysis of the Arabidopsis Replication Timing Program. Plant Physiology. 2018; 176(3):2166-2185. PMID: 29301956, PMCID: PMC5841712. https://www.ncbi.nlm.nih.gov/pubmed/?term=29802212
Goode KM, Petrov D, Vickman RE, Crist SA, Pascuzzi PE, Ratliff TL, Jo Davisson V, Hazbun TR. Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. Biochim Biophys Acta. 2017 May 8. pii: S0304-4165(17)30150-2. doi: 10.1016/j.bbagen.2017.05.006. PMID: 28495207. https://www.ncbi.nlm.nih.gov/pubmed/28495207
Thangamani S, Maland M, Mohammad H, Pascuzzi PE, Avramova L, Koehler CM, Hazbun TR, Seleem MN. Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway. Front Cell Infect Microbiol. 2017 Jan 18;7:4. doi: 10.3389/fcimb.2017.00004. PubMed PMID: 28149831; PubMed Central PMCID: PMC5241286.
https://www.ncbi.nlm.nih.gov/pubmed/28149831
Mani SK, Zhang H, Diab A, Pascuzzi PE, Lefrançois L, , Fares N, Bancel B, Merle P, Andrisani O. EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. J Hepatol. 2016 Nov;65(5):888-898. PubMed PMID: 27238755. https://www.ncbi.nlm.nih.gov/pubmed/27238755
Thangamani S, Eldesouky HE, Mohammad H, Pascuzzi PE, Avramova L, , Hazbun TR, Seleem MN. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. Biochim Biophys Acta. 2016 Oct 3;1861(1 Pt A):3002-3010. PubMed PMID: 27712973. https://www.ncbi.nlm.nih.gov/pubmed/27712973
Ma J, Brennan KJ, D'Aloia MR, Pascuzzi PE, Weake VM. Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development. G3 (Bethesda). 2016 Aug 9;6(8):2435-45. PubMed PMID: 27261002; PubMed Central PMCID: PMC4978897. https://www.ncbi.nlm.nih.gov/pubmed/27261002
Fan H, Zhang H, Pascuzzi PE, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016 Feb 11;35(6):715-26. PubMed PMID: 25893293; NIHMSID: NIHMS671673; PubMed Central PMCID: PMC4615262. https://www.ncbi.nlm.nih.gov/pubmed/25893293
Wendt MK, Williams WK, Pascuzzi PE, Balanis NG, Schiemann BJ, , Carlin CR, Schiemann WP. The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6. Neoplasia. 2015 Jan;17(1):124-33. PubMed PMID: 25622905; PubMed Central PMCID: PMC4309683. https://www.ncbi.nlm.nih.gov/pubmed/25622905

NCBI Bibliography

https://www.ncbi.nlm.nih.gov/sites/myncbi/pete.pascuzzi.1/bibliography/45150274/public/?sort=date&direction=descending

Presentations

Libraries' Presentations

https://web.ics.purdue.edu/~ppascuzz/LibrariesResources_PHRM690_20220223.html

Oral Presentation

Zakharov, W., LI, H., Fosmire, M. J., Traynor, A., Pascuzzi, P. E. (Contributor), 2018 Pacific-Rim Objective Measurement Symposium (PROMS), "Supporting students’ self and peer assessment for writing assignments with Gradient," China. (2018).

Invited panel

Pascuzzi, P. E. (Author & Presenter), ASIS&T Midwest Regional Conference, Innovations in 21st-Century Information Services, "Greasing the Wheels of Biological Big Data Analysis," Association for Information Science & Technology, Columbus, OH, United States. (September 8, 2017).
Barton, A. J. (Panelist), Maybee, C. D. (Panelist), Pascuzzi, P. E. (Panelist), Pouchard, L. (Panelist), Zhang, T. (Panelist), RDAP 2015, "Research Data Integration in the Purdue Libraries," Minneapolis, MN, United States. (April 22, 2015). http://www.slideshare.net/asist_org/rdap-15-research-data-integration-in-the-purdue-libraries.
Barton, A. J., Zhang, T., Pouchard, L. and Pascuzzi, P.E. RDAP Review: Research Data Integration at the Purdue Libraries, Bulletin of the Association for Information Science and Technology, December/January 2016, https://www.asist.org/publications/bulletin/decemberjanuary-2016/rdap-review-research-data-integration-in-the-purdue-libraries/

Peer-reviwed posters

Sapp Nelson, M. (Author & Presenter), Pascuzzi, P. E. (Author), Research Data Access and Preservation Summit, "Developing an active learning graduate data course," ASSIST, Chicago, IL, United States. (March 2018).
Pascuzzi, P. E. (Author & Presenter), Embedding Data Literacy Instruction in an Introductory Bioinformatics Course, Poster: ACRL, Portland, OR, United States. (March 2015).