Pete E Pascuzzi

University Title:
Assistant Professor
Health & Life Sciences
Wilmeth Active Learning Center

Professional Information

Faculty Rank:
Assistant Professor
Liaison Areas:
Biological Sciences
Medicinal Chemistry
Molecular Biosciences
Molecular Pharmacology
Courses Taught:
ILS 590 Independent Study in Information Sciences
ILS 595 Data Management at the Bench
BCHM 695 Introduction to Bioconductor and R
BCHM 498 Research in Biochemistry
BCHM 495 R for Molecular Biosciences
Ph.D. Biochemistry, Cornell University, Ithaca, NY, 2006.
B.A. Biology and Chemistry, Washington & Jefferson College, Washington, PA, 1997.
Professional Experience:
Associate Member, Purdue University Center for Cancer Research, 2015 -
Assistant Professor of Biochemistry (by courtesy), Department of Biochemistry, Purdue University, 2014 -
Assistant Professor, Purdue University Libraries, Purdue University, 2013 -
Research Associate, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 2012 - 2013.
Postdoctoral Research Associate, Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, 2007 - 2012.
Honors and Awards:
The John H. Moriarity Award for Excellence in Service to the Purdue University Libraries, 2018

The Dean's Team Award, Get a G.R.I.P. Task Force, 2015


Corresponding author

Co-corresponding author

  • Wang S, Xing Z, Pascuzzi PE, Tran EJ. Metabolic Adaptation to Nutrients Involves Co-regulation of Gene Expression by the RNA Helicase Dbp2 and the Cyc8 Co-repressor in Saccharomyces cerevisiae. G3 (Bethesda). 2017 May 12. pii: g3.117.041814. doi: 10.1534/g3.117.041814. [Epub ahead of print] PubMed PMID: 28500049.
  • Cloutier SC, Wang S, Ma WK, Al Husini N, Dhoondia Z, , Ansari A, Pascuzzi PE, Tran EJ. Regulated Formation of lncRNA-DNA Hybrids Enables Faster Transcriptional Induction and Environmental Adaptation. Mol Cell. 2016 Feb 4;61(3):393-404. PubMed PMID: 26833086; NIHMSID: NIHMS748935; PubMed Central PMCID: PMC4744127.


  • Goode KM, Petrov D, Vickman RE, Crist SA, Pascuzzi PE, Ratliff TL, Jo Davisson V, Hazbun TR. Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. Biochim Biophys Acta. 2017 May 8. pii: S0304-4165(17)30150-2. doi: 10.1016/j.bbagen.2017.05.006. [Epub ahead of print] PubMed PMID: 28495207.
  • Thangamani S, Maland M, Mohammad H, Pascuzzi PE, Avramova L, Koehler CM, Hazbun TR, Seleem MN. Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway. Front Cell Infect Microbiol. 2017 Jan 18;7:4. doi: 10.3389/fcimb.2017.00004. PubMed PMID: 28149831; PubMed Central PMCID: PMC5241286.
  • Mani SK, Zhang H, Diab A, Pascuzzi PE, Lefrançois L, , Fares N, Bancel B, Merle P, Andrisani O. EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. J Hepatol. 2016 Nov;65(5):888-898. PubMed PMID: 27238755.
  • Thangamani S, Eldesouky HE, Mohammad H, Pascuzzi PE, Avramova L, , Hazbun TR, Seleem MN. Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells. Biochim Biophys Acta. 2016 Oct 3;1861(1 Pt A):3002-3010. PubMed PMID: 27712973.
  • Ma J, Brennan KJ, D'Aloia MR, Pascuzzi PE, Weake VM. Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development. G3 (Bethesda). 2016 Aug 9;6(8):2435-45. PubMed PMID: 27261002; PubMed Central PMCID: PMC4978897.
  • Fan H, Zhang H, Pascuzzi PE, Andrisani O. Hepatitis B virus X protein induces EpCAM expression via active DNA demethylation directed by RelA in complex with EZH2 and TET2. Oncogene. 2016 Feb 11;35(6):715-26. PubMed PMID: 25893293; NIHMSID: NIHMS671673; PubMed Central PMCID: PMC4615262.
  • Wendt MK, Williams WK, Pascuzzi PE, Balanis NG, Schiemann BJ, , Carlin CR, Schiemann WP. The antitumorigenic function of EGFR in metastatic breast cancer is regulated by expression of Mig6. Neoplasia. 2015 Jan;17(1):124-33. PubMed PMID: 25622905; PubMed Central PMCID: PMC4309683.

NCBI Bibliography


Invited panel

Peer-reviwed posters

  • Pete E. Pascuzzi, Embedding Data Literacy Instruction in an Introductory Bioinformatics Course, Poster: ACRL, Portland, OR, March 2015